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The drug ingredients in some ED supplements may interact with prescription drugs in harmful ways. For example, some of them may interact with drugs that contain nitrates, leading to a dangerous decrease in blood pressure. People with diabetes, high blood pressure, high cholesterol, or heart disease often take drugs containing nitrates, and men with these conditions frequently have ED. The Cincinnati-based marketer of Enzyte, Berkeley Nutraceuticals, was reported in 2004 by a Cincinnati newspaper to be the subject of over 3,700 consumer complaints. In early 2006, Berkeley and its subsidiaries reached a settlement with the attorneys general of 18 states and Washington, D.C.